Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics
- Abstract
- AIMS: Cysteinyl leukotrienes are inactivated by acetyl coenzyme A-dependent N-acetyltransferase (NAT). Thus, functional alterations of the NAT gene may contribute to the risk of aspirin-intolerant asthma. MATERIALS & METHODS: Asthmatics (n = 438) were categorized into aspirin-intolerant asthma (15% or greater decrease in the forced expiratory volume in 1 s or cutaneous reactions, n = 170) or aspirin-tolerant asthma (n = 268) groups. In total, 14 polymorphisms of the NAT2 gene were genotyped by a single-base extension method. RESULTS: The distributions of all loci of the 14 SNPs were in Hardy-Weinberg equilibrium (p > 0.05). Among the 14 SNPs, six common SNPs (minor allele frequency >5%) in a Korean population were used for haplotype construction and further statistical analysis. The logistic regression analysis demonstrated that NAT2 -9246G>C and haplotype 2 (TCACGG) were significantly associated with the risk of aspirin-intolerant asthma. The rare allele frequencies of the SNP and Ht2 were significantly higher in the aspirin-intolerant asthma group than in the aspirin-tolerant asthma group (p(corr) = 0.03 and p(corr) = 0.02 in codominant model). CONCLUSION: In a large genetic epidemiology study of aspirin-intolerant asthma in a Korean population, genetic polymorphisms of NAT2 were found to be related to a risk of aspirin hypersensitivity among asthmatics.
- All Author(s)
- J. M. Kim
; B. L. Park
; S. M. Park
; S. H. Lee
; M. O. Kim
; S. Jung
; E. H. Lee
; S. T. Uh
; J. S. Park
; J. S. Choi
; Y. H. Kim
; M. K. Kim
; I. S. Choi
; S. H. Cho
; B. W. Choi
; H. S. Park
; H. S. Chang
; H. D. Shin
; C. S. Park
- Issued Date
- 2010
- Type
- Article
- Keyword
- arylamine N-acetyltransferase; aspirin-induced asthma; cysteinyl leukotriene; SNP
- ISSN
- 1462-2416
- Citation Title
- Pharmacogenomics
- Citation Volume
- 11
- Citation Number
- 7
- Citation Start Page
- 951
- Citation End Page
- 958
- Language(ISO)
- eng
- DOI
- 10.2217/pgs.10.65
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/854
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