Analysis of serum zinc and copper levels in alopecia areata

Abstract

Background As co-factors of metalloenzymes, zinc(Zn) and copper(Cu) have a considerable effect on nearly all the metabolism that takes place in organs of the body, including the skin.

Objective The purpose of this study was to evaluate zinc and copper status in alopecia areata patients.

Methods We measured serum levels of zinc and copper in 30 cases of alopecia areata patients and 10 normal individuals by atomic absorption spectrometry. Furthermore, we studied the significance of the ratio between serum levels of the two metals.

Results The serum levels of zinc were significantly lower in alopecia areata patients than in healthy controls. The serum levels of copper were slightly lower in alopecia areata patients than in healthy controls. Ratios of Cu/Zn were slightly higher in alopecia areata patients than in healthy controls. But their differences were not statistically significant.

Conclusion We suggest that a serum Zn assay should be included in the chemical assessment of patients with alopecia areata.