정신분열병과 양극성 장애의 P300 비교
- Alternative Title
- Comparison of P300 between Schizophrenia and Bipolar Disorder
- Abstract
- Objective : Asymmetries in evoked potential P300 topography of schizophrenia and bipolar disorder are still controversial. The purpose of this study was to examine the difference in P300 topography between schizophrenia and bipolar disorder. Method : P300 was recorded from 16 schizophrenic, 15 bipolar manic, and 16 control subjects. All were right-handed. Subjects silently counted target stimuli(2.0kHz) among trains of standard stimuli(1.0kHz). Averages were constructed from brain responses to target stimuli. Results : 1) Schizophrenics displayed significantly smaller peak amplitude of P300 over Cz, Pz, T3 than controls. 2) Schizophrenics displayed significantly smaller peak amplitude of P300 over T3 than bipolar manics. 3) Schizophrenics displayed significantly smaller peak amplitude of P300 over T3 than their T4. 4) Schizophrenics displayed significantly delayed latency of P300 over T3 than bipolar manics. 5) Schizophrenics displayed significantly delayed latency of P300 over T3 than their T4. Conclusions : Left-sided P300 abnormality, especially left superior temporal gyrus, in schizophrenics relative to bipolar manics and controls suggests that psychophysiological cause of schizophrenia and bipolar disorder is different and P300 asymmetry is specific to the psychophysiological cause of schizophrenia.
- All Author(s)
- 박인준
; 정희연
; 권영준
- Issued Date
- 2001
- Type
- Article
- Keyword
- P300; Schizophrenia; Bipolar disorder
- Publisher
- 대한생물정신의학회
- ISSN
- 1225-8709
; 2005-7571
- Citation Title
- 생물정신의학
Korean Journal of Biological Psychiatry
- Citation Volume
- 8
- Citation Number
- 1
- Citation Start Page
- 123
- Citation End Page
- 130
- Language(ISO)
- kor
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/551
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