대장암에서의 Hypoxia Inducible Factor-1α (HIF-1α) 및 Vascular Endothelial Growth Factor (VEGF): 예후 및 종양표지자로서의 가능성
- Alternative Title
- Expression of Hypoxia-inducible Factor-1α and Vascular Endothelial Growth Factor in Colon Cancer: Relationship to the Prognosis and Tumor Markers
- Abstract
- Purpose: Angiogenesis is one of the key steps in solid tumor growth and metastasis. We investigated the prognostic significance of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1α (HIF-1α) expressions as markers of angiogenesis in colon cancer. Methods: We retrospectively reviewed the medical records of 78 patients with colon or rectal cancer who underwent a surgical resection at Soonchunhyang University Hospital from January 2000 to December 2001, and we evaluated the expression of VEGF and HIF-1α in archival tumor tissues by using immunohistochemistry. We recorded the clinical and the pathological characteristics of the patients and analyzed their survival outcomes. Results: Thirty-four (34) patients were male, and the mean age of all the patients was 66.7 years. HIF-1α and VEGF were positive in 56% (44 patients) and 53% (42 patients) of the tumors, respectively. HIF-1α expression was significantly associated with several pathological parameters, such as TNM stage (P=0.001), lymph node metastasis (P=0.001). HIF-1α expression was also associated with VEGF expression (P=0.032). The survival of patients with HIF-1α expression was worse than that of patients with no HIF-1α expression (P=0.036). However, VEGF expression was not associated with other pathological characteristics. Conclusions: We suggest that, in cases of colorectal cancer, HIF-1α expression may be associated with expression of VEGF, progression of tumors, and poor prognosis.
- All Author(s)
- 최윤영
; 조현득
; 박동국
; 김성용
; 이문수
; 김창호
; 조무식
; 백무준
- Issued Date
- 2008
- Type
- Article
- Keyword
- Colorectal cancer; HIF-1alpha; VEGF; Angiogenesis
- Publisher
- 대한대장항문학회
- ISSN
- 1015-6399
; 1229-8670
; 1976-4111
; 2093-7822
- Citation Title
- 大韓大腸肛門學會誌
Journal of the Korean Society of Coloproctology
- Citation Volume
- 24
- Citation Number
- 5
- Citation Start Page
- 337
- Citation End Page
- 344
- Language(ISO)
- kor
- DOI
- 10.3393/jksc.2008.24.5.337
- URI
- http://schca-ir.schmc.ac.kr//handle/2022.oak/434
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