Transformation of Castleman's disease into follicular dendritic cell sarcoma, presenting as an asymptomatic intra-abdominal mass
- Alternative Title
- 캐슬만병에서 기원하여 무증상 복강 내 종양으로 발현된 여포성 수상돌기 세포육종
- Abstract
- Follicular dendritic cell (FDC) sarcoma is an extremely rare malignant neoplasm arising from FDCs. The exact origin of FDCs remains unclear; both a hematopoietic lineage origin and a stromal cell derivation have been proposed. Proliferation of FDCs can lead to benign reactive lesions or generate neoplastic conditions. The lesions are most commonly found in lymph nodes and usually involve the head and neck area. Castleman's disease is a rare non-neoplasitic lymphoproliferative disorder. Rare cases of hyaline-vascular Castleman's disease have been associated with FDC sarcoma, but a clonal relationship has not been convincingly demonstrated. A pathway toward tumor evolution, beginning with hyperplasia and dysplasia of FDCs, has been proposed. Despite this known association between Castleman's disease and FDC sarcoma, there have only been few reported cases of sarcoma arising as a complication of pre-existing Castleman's disease, especially in abdominal lesions. We describe here a 51-year-old female with an FDC sarcoma arising from unicentric, hyaline-vascular type Castleman's disease in an intra-abdominal mass. Pathologically, the lesion showed a series of changes during the process of transformation from Castleman's disease to FDC sarcoma. (Korean J Gastroenterol 2013;62:131-134).
- All Author(s)
- S. O. Hwang
; T. H. Lee
; S. H. Bae
; H. D. Cho
; K. H. Choi
; S. H. Park
; C. H. Kim
; S. J. Kim
- Issued Date
- 2013
- Type
- Article
- Keyword
- Follicular dendritic cell sarcoma; Castleman's disease
- Publisher
- 대한소화기학회
The Korean Society of Gastroenterology
- ISSN
- 1598-9992
; 2233-6869
- Citation Title
- 대한소화기학회지
The Korean Journal of Gastroenterology
- Citation Volume
- 62
- Citation Number
- 2
- Citation Start Page
- 131
- Citation End Page
- 134
- Language(ISO)
- eng
- DOI
- 10.4166/kjg.2013.62.2.131
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3183
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