Sevoflurane-N2O 마취 중 호기말 이산화탄소 분압에 따른 혈역학적 변화
- Alternative Title
- The hemodynamic changes by different end-tidal CO2 under anesthesia using sevoflurane-N2O
- Abstract
- BACKGROUND
Hypercapnia augments cardiac output and can initiate a sympathetically mediated release of catecholamines to increase cardiac output. Many studies of hemodynamic changes by hypercapnia under general anesthesia with inhalation anesthetics besides sevoflurane. This study examined the hemodynamic changes by increasing end-tidal carbon dioxide (EtCO2) under sevoflurane-N2O anesthesia.
METHODS
Twenty patients were enrolled in the study. We studied stable, mechanically ventilated patients under general anesthesia maintained with O2 2 L/min - N2O 2 L/min - sevoflurane (1.5-2.5 vol%). Hypercapnia were obtained by reducing tidal volume and respiratory rate. EtCO2 was adjusted to 30, 40, 50 mmHg with each concentration maintained for 15 min. Global hemodynamic variables were monitored with a pulmonary artery catheter.
RESULTS
There were no changes in mean arterial pressure or heart rate by hypercapnia. Acute moderate hypercapnia increased cardiac output (4.9 +/- 1.7, 5.5 +/- 1.7, 6.2 +/- 2.1 L/min; P < 0.05), cardiac index (3.0 +/- 0.9, 3.4 +/- 0.9, 3.8 +/- 1.1 L/min/m2; P < 0.05), pulmonary artery pressure (16.9 +/- 3.7, 19.6 +/- 4.2, 23.0 +/- 4.7 mmHg), but did not decrease systemic vascular resistance (1,558.3 +/- 500.4, 1,423.5 +/- 678.6, 1,156.8 +/- 374.0 dynes.sec/cm5; P > 0.05).
CONCLUSIONS
When we changed patient EtCO2 to 30, 40, and 50 mmHg, there were no changes in mean arterial blood pressure and heart rate, but systemic vascular resistance decreased, and cardiac output, cardiac index and mean pulmonary arterial pressure increased significantly.
- All Author(s)
- S. Y. Ok
; H. R. Chun
; Y. H. Baek
; S. H. Kim
; S. I. Kim
; S. C. Kim
; W. Park
; K. Y. Hur
- Issued Date
- 2009
- Type
- Article
- Keyword
- Hemodynamic variables; Hypercapnia; Pulmonary artery catheter; Sevoflurane
- Publisher
- 대한마취통증의학회
Korean Society of Anesthesiologists
- ISSN
- 2005-6419
; 2005-7563
- Citation Title
- Korean Journal of Anesthesiology
- Citation Volume
- 56
- Citation Number
- 2
- Citation Start Page
- 131
- Citation End Page
- 134
- Language(ISO)
- kor
- DOI
- 10.4097/kjae.2009.56.2.131
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/3058
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.