강직성 척추염에 동반된 아밀로이드증이 TNF 억제제로 호전된 1예
- Alternative Title
- TNF-alpha Inhibitor Treatment in an Ankylosing Spondylitis Patient with Secondary Amyloidosis that Manifest with Diarrhea: A Case Report
- Abstract
- Secondary amyloidosis (Amyloid A amyloidosis) occurs when serum amyloid S accumulates in various tissues and organs. It often accompanies chronic inflammatory disease, especially rheumatoid arthritis, as well as ankylosing spondylitis (AS) and Crohn's disease. Although amyloid deposits were reported in 7% of the abdominal fatty tissue samples from AS patients, most of the patients had no symptoms. In a large study, 1.1% of 730 patients with AS were diagnosed with amyloidosis. Most of them showed renal involvement, while none had gastrointestinal symptoms. In South Korea, only a few cases of gastrointestinal involvement of secondary amyloidosis have been reported in AS patients, and there is no report on the effect of a tumor necrosis factor (TNF)-alpha inhibitor. We report a case of secondary amyloidosis in an AS patient who improved with the TNF-alpha inhibitor etanercept.
- All Author(s)
- J. H. Lee
; J. Moon
; H. W. Lee
; S. H. Chang
; E. B. Lee
; Y. W. Song
; E. Y. Lee
- Issued Date
- 2015
- Type
- Article
- Keyword
- Amyloidosis; Spondylitis, Ankylosing; TNFR-Fc fusion protein
- Publisher
- 대한내과학회
Korean Association of Internal Medicine
- ISSN
- 1738-9364
; 2289-0769
- Citation Title
- Korean journal of medicine
- Citation Volume
- 89
- Citation Number
- 2
- Citation Start Page
- 259
- Citation End Page
- 263
- Language(ISO)
- kor
- DOI
- 10.3904/kjm.2015.89.2.259
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2855
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