Sodium Carboxymethyl Cellulose의 심막유착 방지효과에 관한 실험적 연구
- Alternative Title
- A Experimental Study for the Effect of Sodium Carboxymethyl Cellulose on Prevention of Percardial Adhesion
- Abstract
- Background: Pericardial adhesion poses a major problem during re-operative cardiac surgery. The purpose of this study was to determine the effect of sodium carboxymethyl cellulose on experimental pericardial adhesions.
Material and Method: Twenty-four rabbits were divided into 2 groups of 12 rabbits each and pericardial mesothelial injury was induced by abrasion. Group A included rabbits receiving intrapericardial injection of Ringer's solution, and Group B included rabbits receiving intrapericardial injection of 3% sodium carboxymethyl cellulose solution. Three weeks after the surgery, the incidence of adhesions in Group A was compared with that in Group B.
Result: Pericardial adhesions were evaluated by tenacity and type scores. Tenacity scores of 3 or greater were considered clinically significant adhesion. Pericardial adhesion was found in 100% of rabbits in group A. However 25% of the rabbits in Group B had pericardial adhesions(p<0.0001). Type scores were also considered clinically significant between 2 groups.
Conclusion: Our findings demonstrated that intrapericardial injection of 3% sodium carboxymethyl cellulose solution reduced the incidence of pericardial adhesions in an animal models.
- All Author(s)
- S. Y. Lee
; C. W. Jeon
; M. B. Lee
; K. R. Lee
; E. S. Koh
; Y. I. Uhm
- Issued Date
- 2000
- Type
- Article
- Keyword
- Pericardium; Adhesion; Models, experiment
- Publisher
- 대한심장혈관흉부외과학회
The Korean Society for Thoracic & Cardiovascular Surgery
- ISSN
- 0301-2859
; 2233-601X
; 2093-6516
; 2765-1606
; 2765-1614
- Citation Title
- 대한흉부외과학회지
The Korean journal of thoracic and cardiovascular surgery
- Citation Volume
- 33
- Citation Number
- 7
- Citation Start Page
- 541
- Citation End Page
- 546
- Language(ISO)
- kor
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2700
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