Increased plasma nitric oxide metabolites in suicide attempters
- Abstract
- Objective: To evaluate any correlation between plasma levels of nitric oxide metabolites (NO(x)) and suicide attempt.
Method: Plasma NO(x) levels were measured in 53 patients who had recently attempted suicide, 58 non-suicidal psychiatric patients, and 75 normal controls. The severity of suicidal behaviors was evaluated using Weisman and Worden's Risk-Rescue Rating Scale.
Results: Plasma NO(x) levels were significantly higher in suicidal patients than non-suicidal psychiatric patients or normal control subjects (F=11.029, d.f.=2, 183, p<0.001). Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma NO(x) levels than non-suicidal depressive patients (t=-3.090, d.f.=84, p=0.003).
Conclusion: Our study suggests that increased NO production in plasma is associated with suicide attempt, especially in depressive patients.
- All Author(s)
- B. H. Lee
; S. W. Lee
; D. Yoon
; H. J. Lee
; J. C. Yang
; S. H. Shim
; D. H. Kim
; S. H. Ryu
; C. Han
; Y. K. Kim
- Issued Date
- 2006
- Type
- Article
- Keyword
- Suicide; Nitric oxide; Risk-rescue rating scale; Depression; Bipolar disorder; Schizophrenia
- Publisher
- Karger
- ISSN
- 0302-282X
; 1423-0224
- Citation Title
- Neuropsychobiology
- Citation Volume
- 53
- Citation Number
- 3
- Citation Start Page
- 127
- Citation End Page
- 132
- Language(ISO)
- eng
- DOI
- 10.1159/000092542
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2522
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