Plant-derived oxidized nanofibrillar cellulose-chitosan composite as an absorbable hemostat
- Abstract
- In this study, a new absorbable hemostat was developed with two most abundantly found natural polymers. Oxidized nanofibrillar cellulose (ONFC)-chitosan (Ch) sponge was prepared by lyophilization at a volume ratio of 50:50. Cytotoxicity and cell proliferation studies revealed that the sponge was noncytotoxic and the cell proliferated continuously on the sponge. ONFC-Ch sponge showed better hemostatic effect on hepatic trauma than ONFC sponge. Both sponges were implanted on hepatic trauma for 1 and 3 weeks. ONFC-Ch sponge showed greater degree biodegradability and biocompatibility. Thus, ONFC-Ch sponge can be considered as a potential hemostatic material. (C) 2017 Elsevier B.V. All rights reserved.
- All Author(s)
- M. Sukul
; R. D. Ventura
; S. H. Bae
; H. J. Choi
; S. Y. Lee
; B. T. Lee
- Issued Date
- 2017
- Type
- Article
- Keyword
- Absorbable hemostat; Oxidized nanofibrillar cellulose; Chitosan
- Publisher
- Materials Research Society
- ISSN
- 0167-577X
; 1873-4979
- Citation Title
- Materials letters
- Citation Volume
- 197
- Citation Start Page
- 150
- Citation End Page
- 155
- Language(ISO)
- eng
- DOI
- 10.1016/j.matlet.2017.03.102
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2389
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