Current prescription pattern of maintenance treatments for bipolar patients in Korea: A focus on the transition from acute treatments
- Abstract
- Aims: We examined prescription patterns in maintenance treatment for recovered bipolar patients and compared these with acute treatments.
Methods: Using retrospective methods, the bipolar patients in clinical recovery (Clinical Global Impression Bipolar Version score ≤ 2 for 6 months) after acute episode were selected. We reviewed differences between prescription patterns at remission and after a maintenance period of at least 6 months.
Results: A total of 340 bipolar disorder patients were selected. During the maintenance period, more than half of the patients (192, 56.5%) took a mood stabilizer (MS) + antipsychotic (AP) combination. Among the MS, valproate (149, 43.8%) was most prescribed, and lithium (98, 28.8%) was second, but as patients moved into maintenance treatment, lithium use decreased, and the use of lamotrigine (86, 25.3%) increased. Preferred AP were quetiapine (125, 36.8%), aripiprazole (67, 19.7%), risperidone (48, 14.1%), and olanzapine (39, 11.5%). The use of olanzapine in maintenance was greatly decreased compared with that during acute treatment (67, 19.7%). Most patients did not take an antidepressant (AD), but the proportion using one or more AD was increased during maintenance (17.9% to 30.3%), and bupropion (28, 8.2%) was the preferred AD. Doses were decreased in all drugs, but lamotrigine was maintained at a dose of 133.2 ± 68.5 mg/day.
Conclusions: The most common prescription combination for bipolar maintenance treatment was MS + AP. The use of AP was decreased, whereas the use of AD in combination with MS and/or AP was increased. The doses of MS and AP were generally decreased during the maintenance periods, with the exception of lamotrigine.
- All Author(s)
- H. R. Song
; Y. J. Kwon
; W. M. Bahk
; Y. S. Woo
; H. B. Lee
; J. Lee
; D. B. Lee
; S. Y. Lee
; M. D. Kim
; S. Won
; K. Lee
; I. Sohn
; J. G. Lee
; Y. C. Shin
; S. Chung
; S. Jang
; Y. M. Jae
; B. H. Yoon
- Issued Date
- 2016
- Type
- Article
- Keyword
- bipolar disorder; maintenance treatment; recovery
- Publisher
- Blackwell Science
- ISSN
- 1323-1316
; 1440-1819
- Citation Title
- Psychiatry and clinical neurosciences
- Citation Volume
- 70
- Citation Number
- 1
- Citation Start Page
- 42
- Citation End Page
- 50
- Language(ISO)
- eng
- DOI
- 10.1111/pcn.12337
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/2051
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