Plasma surfactant D in patients following acute paraquat intoxication
- Abstract
- Free radical-induced lung injury is a major problem that occurs because of paraquat intoxication. Serum surfactant protein D (SP-D) reflects the severity of various lung diseases. The purpose of this study is to investigate the changes in plasma SP-D concentrations and to correlate disease severity with SP-D concentrations in patients with acute paraqaut intoxication. Twelve paraquat-intoxicated patients participated in this study. Their paraquat exposure was assessed by their plasma's paraquat level. Serial plasma SP-Ds were measured by ELISA. SP-D was decreased two and three days after the initial measurement within 2 to 72 hours of ingestion. There was no difference in initial SP-D levels between survivors and non-survivors. The SP-D test revealed a significant positive correlation between the SP-D level and PaO(2) (r = 0.384, p = 0.003, N = 57). SP-D did not predict the likelihood of survival, but it was positively correlated with PaO(2). This finding suggests that low concentrations of plasma SP-D could reflect hypoxia due to free radical-induced injury.
- All Author(s)
- H. W. Gil
; J. R. Hong
; J. H. Park
; Y. S. Seo
; J. O. Yang
; E. Y. Lee
; S. Y. Hong
- Issued Date
- 2007
- Type
- Article
- Keyword
- Surfactant protein D; Paraquat; Reactive oxygen species
- Publisher
- American Academy of Clinical Toxicology
European Association of Poisons Centres and Clinical Toxicologists
- ISSN
- 1556-3650
- Citation Title
- Clinical Toxicology
- Citation Volume
- 45
- Citation Number
- 5
- Citation Start Page
- 463
- Citation End Page
- 467
- Language(ISO)
- eng
- DOI
- 10.1080/15563650701338138
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1846
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