Comparison of Resolute Zotarolimus-Eluting Stents and Sirolimus-Eluting Stents in Patients With De Novo Long Coronary Artery Lesions A Randomized LONG-DES IV Trial
- Abstract
- Background-Procedural and clinical outcomes still remain unfavorable for patients with long coronary lesions who undergo stent-based coronary interventions. Therefore, we compared the relative efficacy and safety of resolute zotarolimus-eluting stents (R-ZES) and sirolimus-eluting stents (SES) for patients with de novo long coronary lesions. Methods and Results-This randomized, multicenter, prospective trial, called the Percutaneous Treatment of LONG Native Coronary Lesions With Drug-Eluting Stent-IV (LONG-DES IV) trial, compared long R-ZES and SES in 500 patients with long (>= 25 mm) native coronary lesions. The primary end point of the trial was in-segment late luminal loss at 9-month angiographic follow-up. The baseline characteristics were not different between R-ZES and SES groups, including lesion lengths (32.4 +/- 13.5 mm versus 31.0 +/- 13.5 mm, P=0.27). At 9-month angiographic follow-up, the R-ZES was noninferior to the SES with respect to in-segment late luminal loss, the primary study end point (0.14 +/- 0.38 mm versus 0.12 +/- 0.43 mm, P for noninferiority=0.03, P for superiority=0.68). In addition, in-stent late luminal loss (0.26 +/- 0.36 mm versus 0.24 +/- 0.42 mm, P=0.78) and the rates of in-segment (5.2% versus 7.2%, P=0.44) and in-stent (4.0% versus 6.0%, P=0.41) binary restenosis were not significantly different between the 2 groups. There were no significant between-group differences in the rate of adverse clinical events (death, myocardial infarction, stent thrombosis, target-lesion revascularization, and composite outcomes). Conclusions-For patients with de novo long coronary artery disease, R-ZES implantation showed noninferior angiographic outcomes as compared with SES implantation.
- All Author(s)
- J. M. Ahn
; D. W. Park
; Y. H. Kim
; H. Song
; Y. R. Cho
; W. J. Kim
; J. Y. Lee
; S. J. Kang
; S. W. Lee
; C. W. Lee
; S. W. Park
; S. C. Yun
; S. Han
; S. Y. Lee
; B. K. Lee
; J. H. Cho
; T. H. Yang
; N. H. Lee
; J. Y. Yang
; J. S. Park
; W. Y. Shin
; M. H. Kim
; J. H. Bae
; M. K. Kim
; J. Yoon
; S. J. Park
- Issued Date
- 2012
- Type
- Article
- Keyword
- angioplasty; coronary disease; stents
- Publisher
- American Heart Association
- ISSN
- 1941-7640
; 1941-7632
- Citation Title
- Circulation: Cardiovascular Interventions
- Citation Volume
- 5
- Citation Number
- 5
- Citation Start Page
- 633
- Citation End Page
- 640
- Language(ISO)
- eng
- DOI
- 10.1161/CIRCINTERVENTIONS.111.965673
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1757
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