Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes
- Abstract
- Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. Damaged mitochondria DNA (mtDNA) may have a role in regulating hyperglycemia during type 2 diabetes. Circulating cell-free mitochondria DNA (ccf-mtDNA) was found in serum and plasma from patients and has been linked to the prognosis factors in various human diseases. However, the role of ccf-mtDNA in chronic inflammation in type 2 diabetes is unclear. In this study, we hypothesized that the ccf-mtDNA levels are associated with chronic inflammation in patients with type 2 diabetes. The mtDNA levels were elevated in the plasma from patients with type 2 diabetes compared to healthy subjects. The elevated mtDNA levels were associated with interleukin-1 (IL-1)β levels in patients with type 2 diabetes. The mtDNA, from patients with type 2 diabetes, induced absent in melanoma 2 (AIM2) inflammasome-dependent caspase-1 activation and IL-1β and IL-18 secretion in macrophages. Our results suggest that the ccf-mtDNA might contribute to AIM2 inflammasome-mediated chronic inflammation in type 2 diabetes.
- All Author(s)
- J. H. Bae
; S. I. Jo
; S. J. Kim
; J. M. Lee
; J. H. Jeong
; J. S. Kang
; N. J. Cho
; S. S. Kim
; E. Y. Lee
; J. S. Moon
- Issued Date
- 2019
- Type
- Article
- Keyword
- ccf-mtDNA; chronic inflammation; AIM2 inflammasome; type 2 diabetes
- Publisher
- Molecular Diversity Preservation International
- ISSN
- 2073-4409
- Citation Title
- Cells
- Citation Volume
- 8
- Citation Number
- 4
- Citation Start Page
- 328
- Citation End Page
- 328
- Language(ISO)
- eng
- DOI
- 10.3390/cells8040328
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1742
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