The likelihood of having a serum PSA level of ≥2.5 ng/mL according to the degree of fatty liver disease in a screened population
- Abstract
- INTRODUCTION: We sought to investigate the impact of fatty liver disease (FLD) on prostate cancer (PCa) screening by estimating the odds of having a prostate-specific antigen (PSA) value over the cutoff used to prompt for the recommendation of prostate biopsy. METHODS: Between 2007 and 2013, 18 533 native Korean men eligible to receive a serum PSA test, liver profiles, and abdominal ultrasonography were recruited. Logistic regression was used to estimate the odds of an abnormal PSA (≥2.5 ng/mL) in these men (age 45-75 years, PSA≤10 ng/mL) in relation to FLD. The FLD status was categorized as normal, mild, moderate, and severe grade by abdominal sonography. RESULTS: A total of 16 563 men (89.4%) were included in the study after applying the inclusion criteria. Liver profiles were negatively correlated with the serum PSA level. After controlling for age and obesity, there was a statistically significant trend towards a lower likelihood of having a serum PSA level of ≥2.5 ng/mL with severe FLD, having a 34.7% lower likelihood (odds ratio 0.653, 95% confidence interval 0.477-0.88; p<0.01) compared to men in the normal group. CONCLUSIONS: Severe FLD is an independent predictor of a lower likelihood of having abnormal PSA level. Further studies are needed to better define these results in clinical biopsy practice.
- All Author(s)
- J. H. Yoon
; H. J. Yang
; J. H. Kim
; S. W. Doo
; W. J. Yang
; J. Hwang
; S. S. Hong
; S. Park
; D. Y. Cho
- Issued Date
- 2015
- Type
- Article
- Publisher
- Canadian Medical Association
Canadian Urological Association
- ISSN
- 1911-6470
- Citation Title
- Canadian Urological Association Journal
- Citation Volume
- 9
- Citation Number
- 11-12
- Citation Start Page
- E868
- Citation End Page
- E872
- Language(ISO)
- eng
- DOI
- 10.5489/cuaj.2395
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1705
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