Morphologic changes in the spinal cord following intrathecal palonosetron-HCl injection in rats
- Abstract
- Background:
Intravenous palonosetron-HCl, a second-generation antagonist of selective serotonin type 3 (5-HT3) receptors, can prevent chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV). 5-HT3 receptors are abundant in the lower brainstem and the substantia gelatinosa of the spinal cord, which provides a theoretical rationale for neuraxial administration of 5-HT3 receptor antagonists for CINV, PONV, and opioid-induced nausea and vomiting. However, there are no reports of neuraxial administration of palonosetron-HCl. Before neuraxial administration of a drug is accepted for clinical use, its safety must be proven. This study was conducted to determine whether neuraxial administration of palonosetron-HCl produces neurologic injury.
Methods:
Male Sprague-Dawley rats under general anesthesia were catheterized intrathecally and the catheter tip was advanced caudally to the L1 vertebra. After 7 days, 20 μl of normal saline (N group, n = 6) or 20 μl (1 μg) of palonosetron-HCl (P group, n = 6) were injected intrathecally once per day for 2 weeks. Neurotoxic changes were evaluated by light microscopy (LM) and electron microscopy (EM) of the spinal cord. Behavioral changes were also evaluated in both groups.
Results:
One of the N group rats and three of the P group rats demonstrated abnormal behavior during intrathecal drug injection, but otherwise their behavior was normal. The spinal cords of the N group did not have any abnormal findings by LM or EM. The spinal cords of the P group had multiple vacuoles in the white matter by LM, especially in the dorsal funiculus, and EM revealed myelin, axonal, and mitochondrial swelling.
Conclusions:
Results suggest that chronic intrathecal administration of palonosetron-HCl produced microscopic morphologic changes in the spinal cords of rats.
- All Author(s)
- S. H. Yoo
; J. H. Chung
; Y. Seo
; M. K. Choi
; W. K. Choi
; J. B. Kim
- Issued Date
- 2017
- Type
- Article
- Keyword
- Microscopic; Palonosetron; Rats; Spinal injections
- Publisher
- 대한마취통증의학회
- ISSN
- 1226-4857
; 1226-6361
; 1229-1307
; 1975-5171
- Citation Title
- Anesthesia and Pain Medicine
- Citation Volume
- 12
- Citation Number
- 3
- Citation Start Page
- 224
- Citation End Page
- 229
- Language(ISO)
- eng
- DOI
- 10.17085/apm.2017.12.3.224
- URI
- http://schca-ir.schmc.ac.kr/handle/2022.oak/1343
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